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| 1347 |
| | Turkish tribes, besieging Genoese merchants in Caffa, lob the corpses of plague victims over the town walls and thus spread the Black Death | |
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| 1348 |
| | The Black Death, making its way through Europe, is described in vivid detail by Boccaccio who sees its devastating effect in Florence | |
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| c. 1450 |
| | Coffee, derived from wild plants in Ethiopia, is cultivated in Arabia | |
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| c. 1480 |
| | The name of Constantinople changes to Istanbul, a word based on the everyday Greek name for the city | |
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| 1497 |
| | Savonarola, in the carnival before Lent, urges the people of Florence to throw playing cards and lewd images on a great bonfire of vanities | |
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| 1498 |
| | The Florentine mob, weary of puritanism, attacks the convent of San Marco and drags Savonarola away to be hanged and burnt | |
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| 1525 |
| | Luther, a former friar, marries Catherine von Bora, a former nun who has just emerged from her convent | |
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| c. 1585 |
| | The English artist John White paints the everyday life of the Secotan Indians of America | |
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| c. 1590 |
| | Serfdom is introduced in Russia by Boris Godunov, whose measures tie the peasants to the land | |
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| 1596 |
| | A flush toilet is illustrated in an English pamphlet, The Metamorphosis of Ajax by John Harrington | |
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